Detection of QTL affecting fatty acid composition in the pig


We present a QTL genome scan for fatty acid composition in pigs. An F2 cross between Iberian × Landrace pigs and a regression approach fitting the carcass weight as a covariate for QTL identification was used. Chromosomes (Chrs) 4, 6, 8, 10, and 12 showed highly significant effects. The Chr 4 QTL influenced the linoleic content and both the fatty acid double-bond index and peroxidability index. In Chr 6 we found significant associations with the double-bond index and the unsaturated index of fatty acids. Chr 8 showed clear effects on the percentages of palmitic and palmitoleic fatty acids as well as the average chain length of fatty acids. In Chr 10 we detected a significant QTL for the percentage of myristic fatty acid, with an F value that was slightly above the genomewide threshold. The percentage of linolenic fatty acid was affected by a region on Chr 12. A nearly significant QTL for the content of gadoleic fatty acid was also detected in Chr 12. We also analyzed the genomic QTL distribution by a regression model that fits the backfat thickness as a covariate. Some of the QTL that were detected in our analysis could not be detected when the data were corrected by backfat thickness. This work shows how critical the selection of a covariate can be in the interpretation of results. This is the first report of a genome scan detection of QTL directly affecting fatty acid composition in pigs.

DOI: 10.1007/s00335-002-2210-7
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@article{Clop2003DetectionOQ, title={Detection of QTL affecting fatty acid composition in the pig}, author={Alex Clop and Cristina Ovilo and Miguel Perez-Enciso and Albert Cercos and Anna Tomas and Ana Fernandez and Agustina Coll and Josep M. Folch and Carmen Barragan and Isabel Diaz and Maria A. Oliver and Luis Varona and Luis Silio and Armand Sanchez and Jose L. Noguera}, journal={Mammalian Genome}, year={2003}, volume={14}, pages={650-656} }