Detection of Prion Protein in Urine-Derived Injectable Fertility Products by a Targeted Proteomic Approach

@inproceedings{Dorsselaer2011DetectionOP,
  title={Detection of Prion Protein in Urine-Derived Injectable Fertility Products by a Targeted Proteomic Approach},
  author={Alain van Dorsselaer and Christine Carapito and François Delalande and Christine Schaeffer-Reiss and Dani{\`e}le Thiers{\'e} and H{\'e}l{\`e}ne Diemer and Douglas S. McNair and Daniel Krewski and Neil Cashman},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Iatrogenic transmission of human prion disease can occur through medical or surgical procedures, including injection of hormones such as gonadotropins extracted from cadaver pituitaries. Annually, more than 300,000 women in the United States and Canada are prescribed urine-derived gonadotropins for infertility. Although menopausal urine donors are screened for symptomatic neurological disease, incubation of Creutzfeldt-Jakob disease (CJD) is impossible to exclude by non-invasive… CONTINUE READING
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