Detection of NaCl and KCl in TRPV1 knockout mice.

  title={Detection of NaCl and KCl in TRPV1 knockout mice.},
  author={C J G{\'o}mez Ruiz and Stephanie Gutknecht and Eugene R Delay and Sue C Kinnamon},
  journal={Chemical senses},
  volume={31 9},
Both amiloride-sensitive and -insensitive mechanisms contribute to NaCl taste transduction. The amiloride-sensitive mechanism relies on the epithelial Na(+) channel ENaC, which is widely expressed on the apical membrane of fungiform taste cells. The amiloride-insensitive mechanism, which predominates in circumvallate and foliate taste buds, was recently reported to involve a variant of the nonselective cation channel TRPV1. We performed 2-bottle preference and threshold experiments with TRPV1… CONTINUE READING
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The effect of amiloride on operantly conditioned performance in an NaCl taste detection task and NaCl preference in C57BL/6J mice

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