Detection of Mycobacterium tuberculosis in clinical specimens from children using a polymerase chain reaction.

@article{Smith1996DetectionOM,
  title={Detection of Mycobacterium tuberculosis in clinical specimens from children using a polymerase chain reaction.},
  author={Kim Connelly Smith and Jeffrey R. Starke and K. D. Eisenach and Lydia T Ong and M. Denby},
  journal={Pediatrics},
  year={1996},
  volume={97 2},
  pages={155-60}
}
OBJECTIVE We evaluated the usefulness of the polymerase chain reaction (PCR) using the insertion sequence IS6110 as the target for DNA to detect Mycobacterium tuberculosis in clinical specimens from children. STUDY DESIGN This was a prospective, controlled, blinded study comparing PCR on clinical specimens, mycobacterial culture, and clinical diagnosis. PATIENTS Sixty-five hospitalized children were evaluated, 35 with tuberculosis disease and 30 controls. Cases were defined by culture and… CONTINUE READING

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