Detection of Microsatellite Instability by Real Time PCR and Hybridization Probe Melting Point Analysis

@article{Dietmaier2001DetectionOM,
  title={Detection of Microsatellite Instability by Real Time PCR and Hybridization Probe Melting Point Analysis},
  author={Wolfgang Dietmaier and Ferdinand Hofstaedter},
  journal={Laboratory Investigation},
  year={2001},
  volume={81},
  pages={1453-1456}
}
Microsatellite alterations can be found in a number of tumors. There are two types of alterations: loss of heterozygosity (LOH), which can be detected in the majority of colorectal cancers (CRC), and microsatellite instability (MSI). MSI occurs in about 15% of CRC with a mutator phenotype and are the hallmark of hereditary nonpolyposis colorectal cancers (HNPCC). Furthermore, MSI can also be detected in other tumors which are part of the HNPCC tumor spectrum (eg, gastric, ovarian, and… CONTINUE READING
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