Detection of Merkel cell polyomavirus large T-antigen sequences in human central nervous system tumors.

@article{Sadeghi2015DetectionOM,
  title={Detection of Merkel cell polyomavirus large T-antigen sequences in human central nervous system tumors.},
  author={Farzin Sadeghi and Mostafa Salehi-Vaziri and Ahad Alizadeh and Seyed Mohammad Ghodsi and Farah Bokharaei-Salim and Abolfazl Fateh and Seyed Hamidreza Monavari and Hossein Keyvani},
  journal={Journal of medical virology},
  year={2015},
  volume={87 7},
  pages={1241-7}
}
Despite decades of epidemiological investigation, little is known about the etiology of the central nervous system (CNS) tumors, and few well-established risk factors have been recognized. This study tested the presence of Merkel cell polyomavirus (MCPyV), the only member of the Polyomaviridae family convincingly linked to human cancer, in diverse CNS malignancies. In total, 58 CNS tumor biopsies were analyzed for the MCPyV large T-antigen (LT-Ag) gene by quantitative real-time PCR. Merkel cell… CONTINUE READING