Detection of MUC1-expressing mammary carcinoma cells in the peripheral blood of breast cancer patients by real-time polymerase chain reaction.

@article{Cremoux2000DetectionOM,
  title={Detection of MUC1-expressing mammary carcinoma cells in the peripheral blood of breast cancer patients by real-time polymerase chain reaction.},
  author={P de Cremoux and J. M. Extra and Marc G Denis and J. Y. Pierga and Edwige Bourstyn and Claude Nos and Krishna Bentley Clough and Evelyne Boudou and Emmanuel Martin and Annett Mueller and Pierre Pouillart and Henri Magdelenat},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 8},
  pages={3117-22}
}
We have prospectively analyzed blood samples of 122 patients with breast disease for the presence of circulating expressing MUC1 cells before and after treatment. Among them, 28 patients had histologically confirmed benign breast disease (group 1), 34 patients had operable breast cancer (group 2), and 60 patients had advanced breast cancer (group 3). Circulating epithelial cells were isolated with BerEP4-coated immunomagnetic beads. Total RNA was extracted and reverse transcribed before… CONTINUE READING

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