Detection of Leishmania in the blood of early kala-azar patients with the aid of the polymerase chain reaction.

@article{Adhya1995DetectionOL,
  title={Detection of Leishmania in the blood of early kala-azar patients with the aid of the polymerase chain reaction.},
  author={Samit Adhya and Moitrayee Chatterjee and Md Quamarul Hassan and Sandeep Mukherjee and Sandeep Sen},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  year={1995},
  volume={89 6},
  pages={622-4}
}
Samples from 39 patients with symptoms suggestive of early visceral leishmaniasis were independently assayed by microscopy of tissue smears, enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) of blood deoxyribonucleic acid. Of these patients, 19 were confirmed as positive or negative by all 3 tests; 11 patients (28%) negative by smear were positive by ELISA and PCR; and 7 (18%) were positive by PCR alone. These results demonstrate the high sensitivity of the non… CONTINUE READING

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