Detection of KRAS oncogene in peripheral blood as a predictor of the response to cetuximab plus chemotherapy in patients with metastatic colorectal cancer.

@article{Yen2009DetectionOK,
  title={Detection of KRAS oncogene in peripheral blood as a predictor of the response to cetuximab plus chemotherapy in patients with metastatic colorectal cancer.},
  author={Li-Chen Yen and Y. S. Yeh and Chao-wen Chen and H. Wang and Hsiang-Lin Tsai and Chien-Yu Lu and Yu-Tang Chang and Koung-Shing Chu and S Lin and Jaw-Yuan Wang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 13},
  pages={4508-13}
}
PURPOSE Previously we developed membrane-arrays as a promising tool to detect circulating tumor cells (CTC) with KRAS oncogene in patients with malignancies. This study was conducted to determinate the predictive values of CTCs with KARS mutation by membrane-arrays for metastatic colorectal cancer patients treated with cetuximab plus chemotherapy. EXPERIMENTAL DESIGN Seventy-six metastatic colorectal cancer patients receiving cetuximab plus FOLFIRI or FOLFOX-4 chemotherapy were enrolled. KRAS… CONTINUE READING