Detection of KRAS mutations and their associations with clinicopathological features and survival in Chinese colorectal cancer patients.

@article{Li2012DetectionOK,
  title={Detection of KRAS mutations and their associations with clinicopathological features and survival in Chinese colorectal cancer patients.},
  author={Zhihong Li and Yan-Yan Chen and Dan Wang and Gao-hua Wang and Long-jun He and Ji-jiang Suo},
  journal={The Journal of international medical research},
  year={2012},
  volume={40 4},
  pages={1589-98}
}
OBJECTIVE Mutation of the KRAS (v-Kiras2 Kirsten rat sarcoma viral oncogene homologue) gene plays an important role in colorectal tumorigenesis. This study examined associations between KRAS gene mutations and clinicopathological and survival data in Chinese patients with colorectal cancer (CRC). METHODS CRC patients were recruited for the detection of KRAS gene mutations using polymerase chain reaction and DNA sequencing. Data on clinicopathological features and survival times were collected… CONTINUE READING

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