Detection of K-ras mutations in lung carcinomas: relationship to prognosis.

  title={Detection of K-ras mutations in lung carcinomas: relationship to prognosis.},
  author={Phouthone Keohavong and Mary Ann A. DeMichele and A C Melacrinos and Rodney J. Landreneau and Robert J. Weyant and Jill M. Siegfried},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={2 2},
The K-ras mutation is one of the most common genetic alterations found in human lung cancer. To evaluate the prognostic value of ras gene alterations in lung cancer in a U.S. population, we have screened 173 human lung tumors, which included 127 adenocarcinomas, 37 squamous carcinomas, and 9 adenosquamous carcinomas, for mutations in the K-ras gene using the combination of the PCR and denaturing gradient gel electrophoresis. Forty-three tumors contained K-ras mutations. Of these, 41 were… CONTINUE READING
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