Detection of Inferred CCR5- and CXCR4-Using HIV-1 Variants and Evolutionary Intermediates Using Ultra-Deep Pyrosequencing

@inproceedings{Bunnik2011DetectionOI,
  title={Detection of Inferred CCR5- and CXCR4-Using HIV-1 Variants and Evolutionary Intermediates Using Ultra-Deep Pyrosequencing},
  author={Evelien M. Bunnik and Luke C. Swenson and Diana Edo-Matas and Wei Huang and Winnie W. Y Dong and Arne Frantzell and Christos J. Petropoulos and Eoin Coakley and Hanneke Schuitemaker and P. Richard Harrigan and Ang{\'e}lique B van 't Wout},
  booktitle={PLoS pathogens},
  year={2011}
}
The emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants is associated with accelerated disease progression. CXCR4-using variants are believed to evolve from CCR5-using variants, but due to the extremely low frequency at which transitional intermediate variants are often present, the kinetics and mutational pathways involved in this… CONTINUE READING