Detection of HIV-1 in epidermal Langerhans cells of HIV-infected patients using the polymerase chain reaction.

@article{Zambruno1991DetectionOH,
  title={Detection of HIV-1 in epidermal Langerhans cells of HIV-infected patients using the polymerase chain reaction.},
  author={Giovanna Zambruno and Lorenzo Mori and Alessandra Marconi and Nicola Mongiardo and B De Rienzo and U. Bertazzoni and Alberto Giannetti},
  journal={The Journal of investigative dermatology},
  year={1991},
  volume={96 6},
  pages={979-82}
}
Langerhans cells (LC) are bone marrow-derived, HLA-DR+, CD1a+, dendritic antigen-presenting cells found in stratified squamous epithelia. Within resident epidermal cells (EC), LC are the only cells expressing the CD4 antigen and are, therefore, a possible target for human immunodeficiency virus (HIV) infection. To date, conflicting results have been reported on the in vivo infection of LC by HIV. The aim of the present study was to investigate the presence of HIV-1 proviral DNA in epidermal LC… CONTINUE READING
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