Detection of HER2 amplification in circulating free DNA in patients with breast cancer


Background:Human epidermal growth factor receptor 2 (HER2) is amplified and overexpressed in 20–25% of breast cancers. This study investigated circulating free DNA (cfDNA) for detection of HER2 gene amplification in patients with breast cancer.Methods:Circulating free DNA was extracted from plasma of unselected patients with primary breast cancer (22 before… (More)
DOI: 10.1038/bjc.2011.89


6 Figures and Tables