Detection of Fluoroquinolone Resistance Single-Nucleotide Polymorphisms in Neisseria gonorrhoeae gyrA and parC Using MALDI-TOF Mass Spectrometry

Abstract

Many known mechanisms of drug resistance in microorganisms have genetic markers, which are specific genomic changes, mostly single-nucleotide polymorphisms (SNPs). A search for new methods of detecting SNPs is necessary for more efficient identification of resistant strains. A new method was proposed for SNP detection on the basis of minisequencing and/or… (More)
DOI: 10.1007/s11008-005-0099-4

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