Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics.

@article{Kim2009DetectionOF,
  title={Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics.},
  author={Juwon Kim and Tae Sung Park and Jaewoo Song and K Lee and Duk Jin Hong and Yoo Hong Min and June-Won Cheong and Jong rak Choi},
  journal={Cancer genetics and cytogenetics},
  year={2009},
  volume={194 2},
  pages={111-8}
}
Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t… CONTINUE READING