Detection of Epstein‐Barr Virus DNA in Reed‐Sternberg Cells of Hodgkin's Disease Using the Polymerase Chain Reaction and in situ Hybridization

@inproceedings{Uhara1990DetectionOE,
  title={Detection of Epstein‐Barr Virus DNA in Reed‐Sternberg Cells of Hodgkin's Disease Using the Polymerase Chain Reaction and in situ Hybridization},
  author={Hisashi Uhara and Yuichi Sato and Kiyoshi Mukai and Ichiro Akao and Yoshihiro Matsuno and Shuichiroh Furuya and Tomohide Hoshikawa and Yukio Shimosato and Toshiaki Saida},
  booktitle={Japanese journal of cancer research : Gann},
  year={1990}
}
Thirty-one cases of Hodgkin's disease were examined for the occurrence of Epstein-Barr virus (EBV) genome by using the polymerase chain reaction (PCR) of DNA in formalin-fixed paraffin-embedded tissues and in situ hybridization technique. The cases were subdivided into 17 cases of nodular sclerosis (NS), nine cases of mixed cellularity (MC), four cases of lymphocyte predominance (LP), and one case of lymphocyte depletion (LD). EBV DNA was detected in eight cases including four cases of NS… CONTINUE READING
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