Detection of EpCAM positive and negative circulating tumor cells in metastatic breast cancer patients.

@article{Koenigsberg2011DetectionOE,
  title={Detection of EpCAM positive and negative circulating tumor cells in metastatic breast cancer patients.},
  author={Robert Koenigsberg and Eva Obermayr and Giovanna Bises and Georg H Pfeiler and Margit Gneist and Fritz Wrba and Maria de Santis and Robert Zeillinger and M. Hudec and Christian Dittrich},
  journal={Acta oncologica},
  year={2011},
  volume={50 5},
  pages={700-10}
}
BACKGROUND Immunomagnetic EpCAM based methods are used to enrich circulating tumor cells (CTCs) in metastatic breast cancer (mBC) patients. EpCAM negative CTCs may be missed. We addressed the question of the reliability of an EpCAM dependent assay to enrich CTCs. METHODS To elucidate this issue, our study has been designed to assess two different CTC enrichment technologies (i) in EpCAM positive (+) and EpCAM negative cell lines and (ii) in mBC patients in dependency on their respective EpCAM… CONTINUE READING
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