Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease.

  title={Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease.},
  author={T. C. Wu and R. Bruce Mann and Patricia Charache and Stephen D. Hayward and S P Staal and B C Lambe and Richard Frederick Ambinder},
  journal={International journal of cancer},
  volume={46 5},
EBV DNA has been detected by Southern blot hybridization in 20-25% of Hodgkin's disease tumor specimens and localized to the Reed-Sternberg cells by in situ hybridization. In the present investigation we used a 3H-labelled EBER I anti-sense RNA for in situ hybridization of archival formalin-fixed paraffin-embedded Hodgkin's disease specimens previously shown by Southern Blot hybridization to be EBV-positive. In 6 of 8 specimens neoplastic cells showed an intense signal in virtually all of the… CONTINUE READING


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