Detection of DNA sequences using an alternating electric field in a nanopore capacitor.

  title={Detection of DNA sequences using an alternating electric field in a nanopore capacitor.},
  author={Grigori M. Sigalov and Jeffrey Comer and Gregory Timp and Aleksei Aksimentiev},
  journal={Nano letters},
  volume={8 1},
Molecular dynamics simulations revealed that back-and-forth motion of DNA strands through a 1 nm diameter pore exhibits sequence-specific hysteresis that arises from the reorientation of the DNA bases in the nanopore constriction. Such hysteresis of the DNA motion results in detectable changes of the electrostatic potential at the electrodes of the nanopore capacitor and in a sequence-specific drift of the DNA strand under an oscillating transmembrane bias. A strategy is suggested for… 

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