Detection of DNA copy number alterations in cancer by array comparative genomic hybridization

  title={Detection of DNA copy number alterations in cancer by array comparative genomic hybridization},
  author={Evi Michels and Katleen De Preter and Nadine van Roy and Frank Speleman},
  journal={Genetics in Medicine},
Over the past few years, various reliable platforms for high-resolution detection of DNA copy number changes have become widely available. Together with optimized protocols for labeling and hybridization and algorithms for data analysis and representation, this has lead to a rapid increase in the application of this technology in the study of copy number variation in the human genome in normal cells and copy number imbalances in genetic diseases, including cancer. In this review, we briefly… CONTINUE READING

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