Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy.

@article{Schmeiser1996DetectionOD,
  title={Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy.},
  author={Heinz Hans Schmeiser and Christian Bieler and Manfred Wiessler and Charles van Ypersele de Strihou and J. P. Cosyns},
  journal={Cancer research},
  year={1996},
  volume={56 9},
  pages={
          2025-8
        }
}
A unique type of rapidly progressive renal fibrosis, designated Chinese herbs nephropathy (CHN), has been described in young Belgian women who had followed a slimming regimen including recently introduced Chinese herbs (Stephania tetrandra and Magnolia officinalis). Aristolochic acid (AA), a known nephrotoxin and carcinogen, was suspected as its causal factor. To substantiate this hypothesis, renal tissue from five patients with CHN and six patients with other renal diseases was analyzed for… CONTINUE READING

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