[Detection of C gene mutation strain in vertical transmission of hepatitis B virus and its significance].

Abstract

OBJECTIVE This study aims at detecting C gene mutation strain in vertical transmission of hepatitis B virus (HBV). METHODS HBV C gene nt 2,022 - 2,321 was directly sequenced. RESULTS Homology of HBV nucleotide sequence and amino acid sequence in mothers, fathers and their fetus was 100%. Mutation of 2,189 and 2,288 nucleotide of C gene resulted in substitution at the 97th and 130th amino acids. CONCLUSION C gene mutation strain is present in vertical transmission of HBV. Presence of mutation strain may be the cause of failure in vaccination.

Cite this paper

@article{Wang2000DetectionOC, title={[Detection of C gene mutation strain in vertical transmission of hepatitis B virus and its significance].}, author={Songlin Wang and Peng Jiang and G-g Peng and Ning Zeng and Zheng Wang}, journal={Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]}, year={2000}, volume={34 1}, pages={37-8} }