Detection of Borrelia burgdorferi‐specific antigen in antibody‐negative cerebrospinal fluid in neurologic Lyme disease

  title={Detection of Borrelia burgdorferi‐specific antigen in antibody‐negative cerebrospinal fluid in neurologic Lyme disease},
  author={Patricia K Coyle and S E Schutzer and Z Deng and Lauren B. Krupp and Anita Lesgold Belman and Jorge L. Benach and Benjamin J. Luft},
  pages={2010 - 2015}
Objective To determine the potential of detection in CSF of specific Borrelia burgdorferi antigen, OspA, as a marker of infection in neurologic Lyme disease and compare this with the detection of antibody. Design CSF from 83 neurologic patients in an area highly endemic for Lyme disease was examined prospectively for (1) OspA by antigen capture ELISA and Western blot employing monoclonal antibodies, and for (2) B burgdorferi antibodies by ELISA. Results Of the 35 of 83 (42%) patients who were… 

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