Detection of Biofilm in Wounds as an Early Indicator for Risk for Tissue Infection and Wound Chronicity

@article{Vyas2016DetectionOB,
  title={Detection of Biofilm in Wounds as an Early Indicator for Risk for Tissue Infection and Wound Chronicity},
  author={Krishna S. Vyas and Lesley K Wong},
  journal={Annals of Plastic Surgery},
  year={2016},
  volume={76},
  pages={127–131}
}
AbstractWounds are dynamic environments in which dead tissue, exudate, and the bacterial bioburden interact in a complex manner among themselves and with the tissue of the host. Bacteria organize into biofilms, reducing their susceptibility to elimination by the host immune response and antimicrobials. Early detection of biofilms in wounds is crucial to successful chronic wound management; and although many techniques have developed to identify planktonic counterparts in viable wounds, few have… 
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25 Citations
Background Citations
8
Methods Citations
2

25 Citations

Biofilms in Human Health
TLDR
The chapter aims at discussing biofilm development, their influence on human health and difficulties related to biofilm control, and the means of eliminating and controlling them once they have been formed.
Wound Biofilm and Therapeutic Strategies
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The aim of this chapter is to address the current clinical biofilm problem, describe existing and emerging strategies to combat wound biofilm and review the available evidence.
Microbial biofilm in human health - an updated theoretical and practical insight
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The mechanisms involved in biofilm development, biofilm related infections, methods of detection and quantification of microbial communities and therapeutical approaches are described.
Biofilm-related disease
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    Expert review of anti-infective therapy
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This review puts forward a new medical entity that represents a major public health issue, which is named ‘biofilm-related disease’ and highlights the characteristics of biofilm disease including its pathogenesis, microbiological features, clinical presentation, and treatment challenges.
The limitations of in vitro experimentation in understanding biofilms and chronic infection
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A systematic review of the most widely used in vitro biofilm systems is presented, and why they are not always representative of the in vivo biofilms found in chronic infections are discussed.
The Limitations of In Vitro Experimentation in Understanding Biofilms and Chronic Infection.
Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice
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The common microorganisms found in acute and chronic wound infections are summarized, and the challenges from the aspects of clinical diagnosis, non-surgical methods and surgical methods are discussed.
The wound microbiome
Bacterial Aggregates Establish at the Edges of Acute Epidermal Wounds.
TLDR
Bacterial aggregates were observed at the edges of acute epidermal wounds, indicating initiated establishment of a biofilm.
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This article discusses hard-to-heal wounds, the impact they have on patients and healthcare systems, and how biofilms and other factors affect the wound-healing process.
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