• Corpus ID: 14225678

Detection of BCR-ABL proteins in blood cells of benign phase chronic myelogenous leukemia patients.

@article{Guo1991DetectionOB,
  title={Detection of BCR-ABL proteins in blood cells of benign phase chronic myelogenous leukemia patients.},
  author={J. Q. Guo and J Y J Wang and Ralph B. Arlinghaus},
  journal={Cancer research},
  year={1991},
  volume={51 11},
  pages={
          3048-51
        }
}
More than 95% of patients with chronic myelogenous leukemia (CML) contain an abnormal chromosome termed the Philadelphia chromosome (Ph1). Ph1 and the resulting BCR-ABL fused genes are markers for this type of leukemia. The product of the fused BCR-ABL genes is a protein of about 2000 amino acids termed P210 BCR-ABL. Although the BCR-ABL protein can be routinely detected in blood cells from blast crisis CML patients by assaying for its activated tyrosine kinase activity, detection of P210 BCR… 

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TLDR
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