Detection of BCL-6 rearrangements and p53 mutations in Malt-lymphomas.

  title={Detection of BCL-6 rearrangements and p53 mutations in Malt-lymphomas.},
  author={Gianluca Gaidano and Giampiero Volpe and Cristina Pastore and Roberto Chiarle and Daniela Capello and Annunziata Gloghini and Eliana Perissinotto and Francesco Savinelli and Marco Bosco and Umberto Mazza and Stefano A Pileri and Giorgio Palestro and Antonio Carbone and Giuseppe Saglio},
  journal={American journal of hematology},
  volume={56 4},
Twenty-seven lymphomas of mucosa-associated lymphoid tissue (MALT) derived from distinct anatomical sites were tested for the presence of genetic lesions commonly involved in B-cell lymphomagenesis, including activation of proto-oncogenes (BCL-1, BCL-2, BCL-6, and c-MYC), disruption of tumor suppressor loci (p53, 6q), and infection by viruses [Epstein-Barr virus (EBV), and Kaposi's sarcoma-herpesvirus/human herpesvirus-8 (KSHV/HHV-8)]. Sixteen low-grade and 11 high-grade MALT-lymphomas were… CONTINUE READING


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