Detection of Aspergillus fumigatus pulmonary fungal infections in mice with (99m)Tc-labeled MORF oligomers targeting ribosomal RNA.

@article{Wang2013DetectionOA,
  title={Detection of Aspergillus fumigatus pulmonary fungal infections in mice with (99m)Tc-labeled MORF oligomers targeting ribosomal RNA.},
  author={Yuzhen Wang and Ling Chen and Xinrong Liu and Dengfeng Cheng and Guozheng Liu and Yuxia Liu and Shuping Dou and Donald J. Hnatowich and Mary Rusckowski},
  journal={Nuclear medicine and biology},
  year={2013},
  volume={40 1},
  pages={89-96}
}
PURPOSE Invasive aspergillosis is a major cause of infectious morbidity and mortality in immunocompromised patients. The fungus Aspergillus fumigatus (A. fumigatus) is the primary causative agent of invasive aspergillosis. However, A. fumigatus infections remain difficult to diagnose particularly in the early stages due to the lack of a rapid, sensitive and specific diagnostic approach. In this study, we investigated (99m)Tc labeled MORF oligomers targeting fungal ribosomal RNA (rRNA) for the… CONTINUE READING
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