Corpus ID: 37583764

Detection of Aberrant p 16 INK 4 A Methylation in Sera of Patients With HCV Related Liver Disease s : An Egyptian Study

  title={Detection of Aberrant p 16 INK 4 A Methylation in Sera of Patients With HCV Related Liver Disease s : An Egyptian Study},
  author={A. Fouad and R. Ahmed and D. Sabry and E. AbdAlah and M. Kamal},
Egypt reports the highest prevalence of HCV worldwide, the molecular mechanisms of acute hepatitis C virus (HCV) infection, end-stage hepatitis (cirrhosis), and hepatocellular carcinoma have been extensively studied, but little is known of the changes in liver gene expression during the early stages of liver fibrosis associated with chronic HCV infection. The p16INK4A tumor suppressor gene frequently displays genetic alteration in HCC tissues. The present study was performed to estimate the… Expand
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