Detection frequency of human herpesviruses-6A, -6B, and -7 genomic sequences in central nervous system DNA samples from post-mortem individuals with unspecified encephalopathy

@article{Chapenko2015DetectionFO,
  title={Detection frequency of human herpesviruses-6A, -6B, and -7 genomic sequences in central nervous system DNA samples from post-mortem individuals with unspecified encephalopathy},
  author={Svetlana Chapenko and Silvija Roga and Sandra Skuja and Santa Rasa and Maksims Cistjakovs and Simons Svirskis and Zane Zaserska and Valērija Groma and Modra F Murovska},
  journal={Journal of NeuroVirology},
  year={2015},
  volume={22},
  pages={488-497}
}
In this autopsy-based study, human herpesvirus-6 (HHV-6) and -7 (HHV-7) genomic sequence frequency, HHV-6 variants, HHV-6 load and the expression of HHV-6 antigens in brain samples from the individuals, with and without unspecified encephalopathy (controls), using nested and real-time polymerase chain reactions, restriction endonuclease, and immunohistochemical analysis were examined. GraphPad Prism 6.0 Mann-Whitney nonparametric and chi-square test and Fisher’s exact test were used for… CONTINUE READING