Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease

@article{Dubois2010DetectionBV,
  title={Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease},
  author={Albertine Dubois and Anne-Sophie H{\'e}rard and Benoit Delatour and Philippe Hantraye and Gilles Bonvento and Marc Dhenain and Thierry Delzescaux},
  journal={NeuroImage},
  year={2010},
  volume={51},
  pages={586-598}
}
Biomarkers and technologies similar to those used in humans are essential for the follow-up of Alzheimer's disease (AD) animal models, particularly for the clarification of mechanisms and the screening and validation of new candidate treatments. In humans, changes in brain metabolism can be detected by 1-deoxy-2-[(18)F] fluoro-D-glucose PET (FDG-PET) and assessed in a user-independent manner with dedicated software, such as Statistical Parametric Mapping (SPM). FDG-PET can be carried out in… CONTINUE READING

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