Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data.

@article{Bunger2007DetectionAV,
  title={Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data.},
  author={Maureen K. Bunger and Benjamin J. Cargile and Joel R Sevinsky and Ekaterina G. Deyanova and Nathan A. Yates and R. Curtis Hendrickson and James L. Stephenson},
  journal={Journal of proteome research},
  year={2007},
  volume={6 6},
  pages={2331-40}
}
Orthogonal analysis of amino acid substitutions as a result of SNPs in existing proteomic datasets provides a critical foundation for the emerging field of population-based proteomics. Large-scale proteomics datasets, derived from shotgun tandem MS analysis of complex cellular protein mixtures, contain many unassigned spectra that may correspond to alternate alleles coded by SNPs. The purpose of this work was to identify tandem MS spectra in LC-MS/MS shotgun proteomics datasets that may… CONTINUE READING

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