Detection and sequencing of p53 gene mutations in bronchial biopsy samples in patients with lung cancer.

Abstract

We demonstrated the feasibility of detection of p53 gene mutations in bronchial biopsy samples from patients with lung cancer. Following DNA extraction from two to three pieces of bronchial tissue obtained by fiberoptic bronchoscopy, p53 gene mutations were screened using polymerase chain reaction/single-strand conformation polymorphism technique. We… (More)

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