Detection and relevance of germline genetic polymorphisms in glutathione S-transferases (GSTs) in breast cancer patients from northern Indian population

@article{Saxena2008DetectionAR,
  title={Detection and relevance of germline genetic polymorphisms in glutathione S-transferases (GSTs) in breast cancer patients from northern Indian population},
  author={Anubha Saxena and Varinderpal Dhillon and Mohammad Raish and Mohammad Asim and Shabeena Rehman and Nootan Kumar Shukla and Suryanarayan Vishnu Deo and Anjum Ara and Syed Akhtar Husain},
  journal={Breast Cancer Research and Treatment},
  year={2008},
  volume={115},
  pages={537-543}
}
Introduction Glutathione S-transferases (GSTs) are polymorphic superfamily of detoxification enzymes that detoxify therapeutic drugs and various carcinogens. We undertook a case–control study in northern Indian population based sample consisting of 413 patients and 410 controls to evaluate association of null genotype in GSTM1 and GSTT1 along with polymorphism in GSTP1 (A→G) with breast cancer risk. Methods Genotyping analyses were performed by PCR-based methods, and odds ratios (ORs) were… CONTINUE READING