Detection and quantification of residual disease in chronic myelogenous leukemia

@article{Hochhaus2000DetectionAQ,
  title={Detection and quantification of residual disease in chronic myelogenous leukemia},
  author={Andreas Hochhaus and A Weisser and P La Ros{\'e}e and M Emig and M M{\"u}ller and S Sau{\ss}ele and A Reiter and C Kuhn and U Berger and R Hehlmann and N C P Cross},
  journal={Leukemia},
  year={2000},
  volume={14},
  pages={998-1005}
}
The degree of tumor load reduction after therapy is an important prognostic factor for patients with CML. Conventional metaphase analysis has been considered to be the ‘gold standard’ for evaluating patient response to treatment but this technique normally requires bone marrow aspiration and is therefore invasive. The frequency of cytogenetic analyses can be considerably reduced if patients are also monitored by molecular methods, which can be performed on peripheral blood specimens. Of the… CONTINUE READING

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