Detection and quantification of depurinated benzo[a]pyrene-adducted DNA bases in the urine of cigarette smokers and women exposed to household coal smoke.

@article{Casale2001DetectionAQ,
  title={Detection and quantification of depurinated benzo[a]pyrene-adducted DNA bases in the urine of cigarette smokers and women exposed to household coal smoke.},
  author={George P. Casale and Mudita Singhal and Shelley Bhattacharya and Ragulan Ramanathan and Kenneth P. Roberts and Damon C Barbacci and Jianwei Zhao and Ryszard Jankowiak and Michael L Gross and Ercole L Cavalieri and Gerald J. Small and Stephen I. Rennard and Judy L. Mumford and Meilan Shen},
  journal={Chemical research in toxicology},
  year={2001},
  volume={14 2},
  pages={192-201}
}
Polycyclic aromatic hydrocarbons (PAH) are metabolized to electrophiles that can bind to DNA bases and destabilize the N-glycosyl bond, causing rapid depurination of the adducted bases. Recent studies support depurination of DNA as a mechanism central to the genesis of H-ras mutations in PAH-treated mouse skin. Depurinating adducts account for 71% of all DNA adducts formed in mouse skin treated with benzo[a]pyrene (BP). This study analyzed urine of cigarette smokers, coal smoke-exposed women… CONTINUE READING

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