Detection and prevalence of active drug efflux mechanism in various multidrug-resistant Klebsiella pneumoniae strains from Turkey.

@article{Hasdemir2004DetectionAP,
  title={Detection and prevalence of active drug efflux mechanism in various multidrug-resistant Klebsiella pneumoniae strains from Turkey.},
  author={Ufuk Over Hasdemir and Jacqueline Chevalier and Patrice L. Nordmann and Jean-Marie Pag{\'e}s},
  journal={Journal of clinical microbiology},
  year={2004},
  volume={42 6},
  pages={2701-6}
}
The prevalence of active drug efflux pump and porin alterations was investigated in Turkish nosocomial strains of Klebsiella pneumoniae exhibiting a multidrug-resistant phenotype. MICs of various antibiotics, including quinolones, chloramphenicol, tetracycline, and beta-lactams, for those strains were determined either with or without the efflux pump inhibitor phenylalanine arginine beta-naphthylamide (PAbetaN). Thirty-nine percent of the strains exhibited a PAbetaN-modulated resistance for… CONTINUE READING