Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Identifying the genes for genetic hypertension.

@article{Rapp1995DetectionAP,
  title={Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Identifying the genes for genetic hypertension.},
  author={John P. Rapp and Alan Y. Deng},
  journal={Hypertension},
  year={1995},
  volume={25 6},
  pages={1121-8}
}
Identification of the quantitative trait loci that influence blood pressure and cause genetic hypertension is a major challenge. Several genetically hypertensive rat strains exist and can be used to locate by linkage analysis broad chromosomal regions containing blood pressure quantitative trait loci. Such broad chromosomal regions, and the narrower subregions, can be moved among strains (ie, production of congenic strains and congenic substrains) to identify small chromosomal regions… CONTINUE READING

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