Detection and measurement of neurofibromatosis-1 mouse optic glioma in vivo.

Abstract

One of the major limitations to preclinical mouse therapeutic evaluation is the inherent difficulty in imaging small tumors in vivo. We present a rapid and reliable method to detect optic glioma (OPG) in a mouse neurofibromatosis-1 model (Nf1(flox/mut)GFAP-Cre mice) in vivo using Manganese-Enhanced Magnetic Resonance Imaging (MEMRI). In a blinded study, 23… (More)
DOI: 10.1016/j.neuroimage.2007.02.019

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