Detection and kinetic studies of triplex formation by oligodeoxynucleotides using real-time biomolecular interaction analysis (BIA).

Abstract

Real-time biomolecular interaction analysis (BIA) has been applied to triplex formation between oligodeoxynucleotides. 5'-Biotinylated oligonucleotides were immobilised on the streptavidin-coated surface of a biosensor chip and subsequently hybridised to their complementary strand. Sequence-specific triplex formation was observed when a suitable third… (More)

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@article{Bates1995DetectionAK, title={Detection and kinetic studies of triplex formation by oligodeoxynucleotides using real-time biomolecular interaction analysis (BIA).}, author={Phillip Bates and H S Dosanjh and S. Stalin Kumar and Trefor Jenkins and Carla Laughton and Stephen Neidle}, journal={Nucleic acids research}, year={1995}, volume={23 18}, pages={3627-32} }