Detection and identification of proteins using nanoparticle-fluorescent polymer 'chemical nose' sensors.

@article{You2007DetectionAI,
  title={Detection and identification of proteins using nanoparticle-fluorescent polymer 'chemical nose' sensors.},
  author={Chang-Cheng You and Oscar R. Miranda and Basar Gider and Partha Sakha Ghosh and Ik-Bum Kim and Belma Erdoğan and Sai Archana Krovi and Uwe H F Bunz and Vincent M Rotello},
  journal={Nature nanotechnology},
  year={2007},
  volume={2 5},
  pages={318-23}
}
A sensor array containing six non-covalent gold nanoparticle-fluorescent polymer conjugates has been created to detect, identify and quantify protein targets. The polymer fluorescence is quenched by gold nanoparticles; the presence of proteins disrupts the nanoparticle-polymer interaction, producing distinct fluorescence response patterns. These patterns are highly repeatable and are characteristic for individual proteins at nanomolar concentrations, and can be quantitatively differentiated by… CONTINUE READING

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