Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy.

@article{Griffioen2006DetectionAF,
  title={Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy.},
  author={Marieke Griffioen and Jan H. Kessler and Martina Borghi and Ronald A van Soest and Caroline E. van der Minne and Jan Nouta and Sjoerd H van der Burg and Jan Paul Medema and Peter Schrier and J H Frederik Falkenburg and Susanne Osanto and Cornelis J M Melief},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 10},
  pages={3130-6}
}
PURPOSE Preferentially expressed antigen on melanomas (PRAME) is an interesting antigen for T-cell therapy because it is frequently expressed in melanomas (95%) and other tumor types. Moreover, due to its role in oncogenic transformation, PRAME-negative tumor cells are not expected to easily arise and escape from T-cell immunity. The purpose of this study is to investigate the usefulness of PRAME as target for anticancer T-cell therapies. EXPERIMENTAL DESIGN HLA-A*0201-subtyped healthy… CONTINUE READING

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