Detection and follow-up of fibroblast growth factor receptor 3 expression on bone marrow and circulating plasma cells by flow cytometry in patients with t(4;14) multiple myeloma.

@article{Chandesris2007DetectionAF,
  title={Detection and follow-up of fibroblast growth factor receptor 3 expression on bone marrow and circulating plasma cells by flow cytometry in patients with t(4;14) multiple myeloma.},
  author={Maria Olivia Chandesris and J Steve Soulier and Sylvaine Labaume and Antoine Crinquette and Laetitia Repellini and Karine Chemin and Marion Malphettes and Claire Fieschi and Bouchra Asli and Yurdagul Uzunhan and Jean Paul Fermand and Jean Christophe Bories and Bertrand Arnulf},
  journal={British journal of haematology},
  year={2007},
  volume={136 4},
  pages={609-14}
}
The t(4;14)(p16;q32) translocation, found in 15% of multiple myeloma (MM) cases, indicates a poor prognosis. Plasma cells (PC) with t(4;14) ectopically express the fibroblast growth factor receptor 3 (FGFR3) tyrosine kinase receptor, which has potential transforming activity and may represent a therapeutic target. To detect FGFR3 protein expression, bone marrow (BM) aspirate from 200 consecutive newly diagnosed (n = 116) or relapsing (n = 74) MM patients was studied by flow cytometry (FC) using… CONTINUE READING
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…