Detection and estimation of azomethane in expired air of 1,2-dimethylhydrazine-treated rats.

@article{Fiala1976DetectionAE,
  title={Detection and estimation of azomethane in expired air of 1,2-dimethylhydrazine-treated rats.},
  author={Emerich S. Fiala and Callie Kulakis and George Bobotas and JohnH. Weisburger},
  journal={Journal of the National Cancer Institute},
  year={1976},
  volume={56 6},
  pages={
          1271-3
        }
}
Azomethane (AM) gas was identified as a major metabolite of 1,2-dimethylhydrazine (1,2-DMH) in the expired air of F344 rats. The compound was characterized by high-pressure liquid chromatography, gas chromatography, and mass spectrometry, in comparison to a synthetic standard. At a dose of 21 mg 1,2-DMH/kg sc, approximately 14 and 11% of the dose were exhaled as AM and CO2, respectively, in 24 hours. At 200 mg 1,2-DMH/kg, 23 and 4% of the dose appeared as AM and CO2, respectively, in the… CONTINUE READING
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