Detection and downregulation of type I IGF receptor expression by antibody-conjugated quantum dots in breast cancer cells

@article{Zhang2008DetectionAD,
  title={Detection and downregulation of type I IGF receptor expression by antibody-conjugated quantum dots in breast cancer cells},
  author={Hua Zhang and Deepali Sachdev and Chun Wang and Allison Hubel and Martine Gaillard-Kelly and Douglas Yee},
  journal={Breast Cancer Research and Treatment},
  year={2008},
  volume={114},
  pages={277-285}
}
The type I insulin-like growth factor (IGF) receptor (IGF1R) is a transmembrane tyrosine kinase involved in breast cancer proliferation, survival, and metastasis. Several monoclonal antibodies directed against the receptor are in clinical trials. In order to develop a methodology to detect and measure IGF1R levels in breast cancer cells, we covalently conjugated an IGF1R antibody, AVE-1642, with quantum dots (Qdots), which are nanocrystals that emit fluorescence upon excitation. AVE-1642 Qdots… CONTINUE READING