Detection and comparison of EGFR mutations in matched tumor tissues, cell blocks, pleural effusions, and sera from patients with NSCLC with malignant pleural effusion, by PNA clamping and direct sequencing.

@article{Yeo2013DetectionAC,
  title={Detection and comparison of EGFR mutations in matched tumor tissues, cell blocks, pleural effusions, and sera from patients with NSCLC with malignant pleural effusion, by PNA clamping and direct sequencing.},
  author={Chang Dong Yeo and Jin Woo Kim and Kwan Hyoung Kim and Jick Hwan Ha and Chin Kook Rhee and Seung Joon Kim and Young Kyoon Kim and Chan Kwon Park and Sang Haak Lee and Mi Sun Park and Hyeon Woo Yim},
  journal={Lung cancer},
  year={2013},
  volume={81 2},
  pages={207-12}
}
Peptide nucleic acid (PNA)-mediated real-time PCR clamping has higher sensitivity than conventional direct sequencing for detecting mutations. Pleural effusion and serum may provide good samples in which to detect epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) patients. We studied 37 NSCLC patients with malignant pleural effusion. EGFR mutations were assessed by PNA clamping and direct sequencing using tumor tissues, cell blocks, pleural effusion, and… CONTINUE READING

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