Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells

@article{Fehm2009DetectionAC,
  title={Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells},
  author={Tanja N. Fehm and Oliver Hoffmann and Bahriye Aktas and Sven Becker and Erich Franz Solomayer and Diethelm Wallwiener and Rainer Kimmig and Sabine Kasimir-Bauer},
  journal={Breast Cancer Research : BCR},
  year={2009},
  volume={11},
  pages={R59 - R59}
}
The role of circulating tumor cells (CTCs) in blood of primary breast cancer patients is still under investigation. We evaluated the incidence of CTCs in blood, we evaluated the correlation between CTCs and disseminated tumor cells (DTCs) in the bone marrow (BM), and we characterized CTCs for the expression of HER2, the estrogen receptor (ER) and the progesterone receptor (PR). Blood of 431 patients with primary breast cancer were analyzed for EpCAM, MUC1 and HER2 transcripts with the AdnaTest… CONTINUE READING