Detection and characterization of Sp1 binding activity in human chondrocytes and its alterations during chondrocyte dedifferentiation.

@article{Dharmavaram1997DetectionAC,
  title={Detection and characterization of Sp1 binding activity in human chondrocytes and its alterations during chondrocyte dedifferentiation.},
  author={Rita M. Dharmavaram and Gang Liu and S D Mowers and Sergio A Jimenez},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 43},
  pages={26918-25}
}
We have detected DNA binding activity for a synthetic oligonucleotide containing an Sp1 consensus sequence in nuclear extracts from human chondrocytes. Changes in the levels of Sp1 oligonucleotide binding activity were examined in nuclear extracts from freshly isolated human chondrocytes, from chondrocytes that had been cultured under conditions that… CONTINUE READING