Detection and analysis of autophagy in the American alligator (Alligator mississippiensis).

@article{Hale2020DetectionAA,
  title={Detection and analysis of autophagy in the American alligator (Alligator mississippiensis).},
  author={Amber Hale and Mark Merchant and Marie Elinor White},
  journal={Journal of experimental zoology. Part B, Molecular and developmental evolution},
  year={2020}
}
In response to environmental temperature depression in the fall and winter, American alligators (Alligator mississippiensis) brumate. Brumation is characterized by lethargy, fasting, decreased metabolism, and decreased body temperature. During brumation, alligators will periodically emerge for basking or other encounters when environmental conditions permit. This sporadic activity and lack of nutrient intake may place strain on nutrient reserves. Nutrient scarcity, at the cellular and/or… 

References

SHOWING 1-10 OF 79 REFERENCES

The machinery of macroautophagy

This review focuses on macroautophagy, briefly describing the discovery of this process in mammalian cells, discussing the current views concerning the donor membrane that forms the phagophore, and characterizing the autophagy machinery including the available structural information.

Antibacterial properties of serum from the American alligator (Alligator mississippiensis).

Determining Atg protein stoichiometry at the phagophore assembly site by fluorescence microscopy

A fluorescence microscopy-based method is used to study the stoichiometry of Atg proteins at the PAS, trying to explain the mechanism of how the vesicle formation process is precisely regulated.

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

The mammalian homologue of Atg9p, a multi-spanning transmembrane protein essential in yeast for autophagy, is studied to gain a better understanding of the function of this ubiquitious protein.

An overview of autophagy: morphology, mechanism, and regulation.

Current knowledge of the morphology, molecular mechanism, and regulation of mammalian autophagy is described, which will aid in the development of new treatments for human diseases in which autphagy is not functioning properly.

Essential role for Nix in autophagic maturation of erythroid cells

It is suggested that Nix-dependent loss of ΔΨm is important for targeting the mitochondria into autophagosomes for clearance during erythroid maturation, and interference with this function impairs erythyroidmaturation and results in anaemia.

Autophagy

This review provides an overview of autophagy, the types of autphagy, its regulation and its known impact on development gleaned primarily from murine models.
...