Detection and Removal of Biases in the Analysis of Next-Generation Sequencing Reads

@inproceedings{Schwartz2011DetectionAR,
  title={Detection and Removal of Biases in the Analysis of Next-Generation Sequencing Reads},
  author={Schraga Schwartz and Ram Oren and Gil Ast},
  booktitle={PloS one},
  year={2011}
}
Since the emergence of next-generation sequencing (NGS) technologies, great effort has been put into the development of tools for analysis of the short reads. In parallel, knowledge is increasing regarding biases inherent in these technologies. Here we discuss four different biases we encountered while analyzing various Illumina datasets. These biases are due to both biological and statistical effects that in particular affect comparisons between different genomic regions. Specifically, we… CONTINUE READING
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